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M94A2411.TXT
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1994-10-25
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Document 2411
DOCN M94A2411
TI A score with immunological, virological and clinical features to
estimate HIV progression in perinatal HIV-infection.
DT 9412
AU Mentzer D; Funk M; Sehrt P; Cinatl J; Pfeiffer A; Steiner JJ; Dorr HW;
Kreuz W; Centre of Pediatrics, University Frankfurt am Main, Germany.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):310 (abstract no. PC0169). Unique
Identifier : AIDSLINE ICA10/94370164
AB OBJECTIVE: Progression of HIV-infection is difficult to predict by
laboratory data. The following score was used to characterize
progression of HIV- disease in perinatally infected children: TABULAR
DATA, SEE ABSTRACT VOLUME. Flow cytometric evaluation: CD4(+) cell
count, assay of syncytium forming units (SFU) in lymphocyte culture,
quantitative p-24 antigen-ELISA in serum, lean body mass (LBM) (*sex-
and age- adjusted) registered by bioelectrical impedance analysis.
PATIENTS: This investigation presents data from 10 perinatally HIV-
infected children, age 7-10 years. 3 children are classified as P1
(CDC), 4 children as P2 (CDC) and 3 as AIDS. RESULTS: All patients in P1
showed normal CD4(+) cell count, no p-24 Antigen and non SI virus
strain. All patients in P2 had CD4(+) cell count > 250/microliters, in
one child p-24 Ag > 100 pg/ml and in one patient SI-virus strains was
found. All patients in AIDS had CD4(+) cell count < 250/microliters and
p-24 Ag > 100 pg/ml, in all children SI-virus strain were found.
Patients in P1 and P2 showed normal LBM. In patients with AIDS LBM was
over 80%. DISCUSSION: A single parameter seems not to be sufficient to
estimate HIV progression. Long term surviver showed no significant
alterations in all 4 parameters. Beside CD4 cell decline the occurrence
of SI virus strains was the most specific among the score-parameters in
heralding rapid disease progression. Results and multivariance-analysis
of all score-parameters will be demonstrated in detail.
DE Body Mass Index Child Female Flow Cytometry Giant Cells/MICROBIOLOGY
Human HIV Core Protein p24/ANALYSIS HIV
Infections/*DIAGNOSIS/TRANSMISSION Leukocyte Count Lymphocyte
Transformation Pregnancy *Pregnancy Complications, Infectious T4
Lymphocytes MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).